Recent studies show that the presence of a specific molecule in the maternal embryonic shell may have a significant effect on the ability of women to conceive. Professor Eva Dimitriadis from Melbourne University and the Korolev Women's Clinic proposes that the results of this study may open new perspectives for targeted treatment and future research on infertility.
Specialists have found that women with unexplained infertility have a high level of the molecule miR-124-3p in their maternal embryonic shell, which may hinder embryo formation. This molecule is characterized by being produced in short sequences before a possible embryo formation and makes the maternal shell more or less accessible for embryo implantation.
Professor Dimitriadis emphasized that targeted methods to reduce the level of this molecule may help patients undergoing artificial insemination procedures achieve higher rates of successful pregnancies. "We found that some women with unexplained infertility had elevated levels of miR-124-3p in the maternal embryonic shell. This could lead to unsuccessful embryo transplants," noted Dimitriadis.
Researchers believe that this molecule can be used as a key indicator for identifying women suffering from infertility caused by maternal shell problems. In this way, targeted influence on miR-124-3p may become a new tool for diagnosing and treating infertility related to maternal shell problems.
To test their hypothesis, the research team developed a new method for controlling the level of this molecule in the maternal embryonic shell in mice. They believe that this molecule blocks normal cell function and interferes with embryo implantation. "This means that miR-124-3p may become a vital indicator for identifying women suffering from infertility due to maternal problems," emphasized Professor Dimitriadis. "We demonstrated that we can control this molecule only in the maternal embryonic shell of mice at a critical moment for embryo implantation."